Creatine Phosphate Consumption and the Actomyosin Crossbridge Cycle in Cardiac Muscles
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چکیده
منابع مشابه
Creatine phosphate consumption and the actomyosin crossbridge cycle in cardiac muscles.
To investigate the regulation of the actomyosin crossbridge cycle in cardiac muscles, the effects of ATP, ADP, Pi, and creatine phosphate (CP) on the rate of force redevelopment (ktr) were measured. We report that CP is a primary determinant in controlling the actomyosin crossbridge cycling kinetics of cardiac muscles, because a reduction of CP from 25 to 2.5 mmol/L decreased ktr by 51% despite...
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Creatine phosphate serves as a reuseable high energy phosphate reservoir in skeletal and cardiac muscle and in the brain. These stores of creatine phosphate are thought to rephosphorylate the ATP hydrolyzed during cellular work (see 1 and 2 for review). Studies in our laboratory (3) have shown that mononuclear phagocytes obtained from the peritoneal cavities of mice also contain large stores of...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000080536.06932.e3